Avros:
| Key | Found | Unlocks |
| Begora's Sanctuary | ||
| Frost Giant's Keep | ||
| a burnished silver collar | A hermit | ? |
| a large iron key | A hermit, An elderly giant | ? |
| a large silver key | A spectral guard, The frost giant queen | Door north of the queen |
| a Remorhaz scale | A remorhaz | Door west of him |
| Jalur Lumber Camp | ||
| Ogre Village | ||
| Old Stargazer Clan Hall | ||
| Tellerium | ||
| an inn key to room # | Klinn | Inn rooms |
| an inn key | Addison Fink, the innkeeper | Inn rooms |
| Templeton | ||
| a house key | A content citizen | ? |
| a fizzing lead key | The alchemist's faithful servant | Unlocks the door into the alchemist at the top of the tower. |
| a key | A brigand lieutenant | ? |
| the key of the dead | The spirit of Lord Templeton | Unlocks the south door from Throne Room to Treasury - Chest Removed (Tam) |
| a bloody key | Thanatosis | Hidden west in The Royal Bedroom on the second floor to the Alchemist |
| a golden-plated key | An alchemist | Locked north on the second floor hallway to The Royal Armory |
| a key enchanted with an ancient benediction | Thanatosis | Tellerium prison miniquest |
| Catacombs of Shame | ||
| The Fishing Village of Dorathon | ||
| The Hamlet of Winton | ||
| The Village of Muldar Lohk Mulvar | ||
| a small steel key | A stout gateguard | Before a Wooden Palisade - The door east |
| Tower of Aroxa | ||
| a blackened metal key | ? | ? |
| a blackened metal key | ? | ? |
| a blackened metal key | ? | ? |
| a blackened metal key | ? | ? |
| a blackened metal key | ? | ? |
Auryn:
| Key | Found | Unlocks | ||
| Emperor's Crossroads | ||||
| a chambermaid's key | A meek looking serving boy | ? | ||
| Mount Vesuvius | ||||
| a small key of marble | Wyglif the Wise | ? | ||
| a strange key | An elemental paladin | ? | ||
| a brilliant white key | Syrazic | ? | ||
| a glowing red key | Pythax | ? | ||
| a shining yellow key | Stepha | ? | ||
| a flat basalt key | Zizziks | ? | ||
| Old Amaunet Clan Hall | ||||
| Old Armageddon Clan Hall | ||||
| Palace of Diocletian | ||||
| a used wooden key | ? | ? | ||
| Sigil | ||||
| unicorn key | delicate jewelry box | hidden east in the gallery | ||
| Vospire | ||||
| a large golden key | The King of Vospire | ? | ||
| the lair key | The Ash Dragon | The door to the ash dragon | ||
| a key enchanted with an ancient benediction | The Warden | Tellerium prison miniquest | ||
Beltane:
| Key | Found | Unlocks |
| Pirates Cove | ||
| Maldra Keep | ||
| Dungeon Deceit | ||
| Chanctonbury Woods | ||
| Gorth | ||
| Takhtin | ||
| The Indestructible Cenotaphy | ||
| The Village of Colyon | ||
| The Village of Mulakanathos | ||
| Xalt, Unseelie Outpost | ||
Sepharia:
| Key | Found | Unlocks |
| Lowangen | ||
| a key enchanted with an ancient benediction | The prison captain | Tellerium Prison miniquest |
| The key to Tyr's coffin | ? | ? |
| Hydra's Den | ||
| a thin, brittle key | A newborn xorn-hydra crossbreed | ? |
| An Abandoned Lighthouse | ||
| a tarnished brass key | The ghost of Jack | ? |
| Lasler | ||
| A key | ? | ? |
| Towne Of Rune | ||
| Griffon Hotel Room # Key | Desk Clerk | Hotel doors |
| a brass key | ? | ? |
| a camelhair paintbrush | ? | ? |
| a golden key | ? | ? |
| a standard room key | Sathan | Naughties room in the Lonely Dragon Inn |
| ornate, silver, heart-shaped key | ? | ? |
| Runic Castle | ||
| a bar of chocolate | The Court Jester | sw courtyard door |
| a convoluted key | ? | ? |
| a large iron key | A castle attendant | castle wall corner doors |
| Focault's Residence | ||
| a black key | ? | ? |
| a skeleton key | ? | ? |
| an iron key | ? | ? |
| Temple Crypt | ||
| a tarnished silver key | The pit fiend | ? |
| Rune Graveyard | ||
| a black onyx key | ? | ? |
| a faceted mithril key | ? | ? |
| a shimmering key | ? | ? |
| a small silver key | ? | ? |
| a stone key | ? | ? |
| a tarnished copper key | ? | ? |
| a wisp of fog | ? | ? |
| a worn iron key | ? | ? |
| an iron crowbar | ? | ? |
| New Kolvir | ||
| a glass key | ? | ? |
| a heavy, mahogany key | ? | ? |
| a small obsidian key | ? | ? |
| New Rigel | ||
| a key | Innkeepers | Inn rooms |
| a room key | Macafee | Inn room |
| Xaventry | ||
| a ceramic key | ? | ? |
| a copper-plated wooden key | ? | ? |
| a courtroom key | ? | ? |
| a crimson key | ? | ? |
| a crystal key decorated with boulders | priest of maradas | temple of maradas |
| a crystal key decorated with cyclones | ? | ? |
| a crystal key decorated with flames | ? | ? |
| a crystal key decorated with nothingness | ? | ? |
| a crystal key decorated with waves | ? | ? |
| a glass key | ? | ? |
| a gold-plated wooden key | ? | ? |
| a porcelain key | ? | ? |
| a prison cell key | ? | ? |
| a ruby key | The lost caverns | temple of maradas |
| a rusted iron key | ? | ? |
| a sapphire key | The lost caverns | temple of maradas |
| a shiny brass key | ? | ? |
| a silver-plated wooden key | ? | ? |
| a small brass key | ? | ? |
| a small copper inn key | ? | ? |
| a small inn key | ? | ? |
| a small iron inn key | ? | ? |
| a small temple key | priest of marads | temple of maradas |
| a wooden inn key | ? | ? |
| a wooden key | ? | ? |
| an emerald key | ? | ? |
| an inn key | ? | ? |
| an iron gate key | ? | ? |
| an obsidian key | ? | ? |
| Lonely Dragon Inn | ||
| frothing unicorn horn | frothing unicorn | a delicate jewelry box |
| Dungeon Wroth | ||
| a golden key | Displacer beast | Door to the second floor |
| a red key | a titan | Chest in the miners area |
| a white key | ? | ? |
| a skull key | ? | Chests on second floor |
| a silver key | The High Priest of the Portal | ? |
| an iron key | ? | ? |
| Dungeon Avarice | ||
| a bloody key made of bone | ? | ? |
| a collector's key | A frost giant child | ? |
| a huge bone key | ? | ? |
| an ice covered key | ? | ? |
| large key made of bone | ? | ? |
| small bloody key | ? | ? |
| Mandrake Woods | ||
| a rusty prison key | ? | ? |
| an iron key | ? | ? |
| Shadow Castle | ||
| a cold black stone brick | ? | ? |
| a cold black stone key | ? | ? |
| a large bone key | ? | ? |
| an ancient iron key | ? | ? |
| small ethereal key | ? | ? |
| Tavern of the boars | ||
| a small silver key | ? | ? |
| Tower of art | ||
| a golden key | ? | ? |
| a house key | ? | ? |
| shiny key | ? | ? |
| a skeleton key | ? | ? |
| a small silver key | ? | ? |
| a strange key | ? | ? |
Fairie Plane:
| Cavhfail | ||
| a key of deception | The elder | ? |
| a black metal key | A covert operations special agent | ? |
| a key enchanted with an ancient benediction | The prison warden | Tellerium prison miniquest |
| Eanoss Azelmar | ||
| a small crystalline key | Sonatari | ? |
| Engineers Exclave | ||
| Frosthold | ||
| Human Outpost | ||
| Rahdiyr | ||
| a room key | The Faerie Inn innkeeper | ? |
| a suite key | The Faerie Inn innkeeper | ? |
| a small key | The Faerie Inn innkeeper | ? |
| a heavy silver key | An entrance guard | ? |
| a trunk key | The head cavern guard | ? |
| Rimeward | ||
| Seelie Castle | ||
| a large key | An overlord of Seelie | ? |
| a copper key | A senior advisor of Seelie | ? |
| a tiny key | A wise advisor | ? |
| Unseelie Castle | ||
| a dirty black key | The warden of Unseelie Castle | ? |
| a rusted key | General Hesieno | ? |
| a key enchanted with an ancient benediction | ? | Tellerium Prison Miniquest |
Great Alyrian Underground:
| Key | Found | Unlocks |
| Bartlett's Summer Retreat | ||
| Hotel Hello | ||
| Isle of The Sea Hag | ||
| Kessarian's Dungeon | ||
| Smuggler's Cave | ||
| Smuggler's Gulch | ||
| The Chattering Skull Tavern | ||
| The Sacred Temple of the Tentacle Cult of Metonychoseuthis, with Swiveling Hooks | ||
| The Seeress' Fogchamber | ||
| Three-Bearded Jake's | ||
| Towne of Decara | ||
| Vir | ||
Sigil Underground:
| Key | Found | Unlocks |
| A Fiery Catwalk | ||
| A Ghost Town | ||
| A Labyrinthine Molehill | ||
| Bandit Camp | ||
| a small steel key | Hesario the Bandit King | Room to the right with the ill gypsy girl in |
| Darksea | ||
| Genauras | ||
| a closet key | Professor Ordunvec | ? |
| a key with a skull and crossbones | Professor Ordunvec | ? |
| a key with a skull and crossbones | Firon | ? |
| Gourevitch's Hideaway | ||
| Gypsy Village | ||
| The Remnants of a Caldera | ||
| Troglodyte Village | ||
| a prison cell key | A robust guard | ? |
| a guard's key | A troglodyte guardian, Chief Craggma Oog | ? |
Miscellaneous Locations:
| Key | Found | Unlocks |
| Aequtus | ||
| ?? | ?? | Down at back of main deck (ship through glacial wall) |
| Arcane Archipelago | ||
| Atlantis | ||
| A Forsaken Oil Well | ||
| An Abandoned Oil Well | ||
| Glarshak | ||
| Hellbent Mountain | ||
| Irda Isle | ||
| Irda Isle Caverns | ||
| The Proving Grounds | ||
| Domain of Arbaces | ||
| Magencia | ||
| Naulitas | ||
| Palamire | ||
| Shlarksh | ||
| Strange Ruins | ||
| Stronghold Of The Garbool Tribe | ||
| The Saucy Wench Tavern | ||
| The Wandering Sidhe | ||
| Tower of Riga | ||
| Wreck of the Fiesty Wench | ||